Persistent measles infection in malnourished children.

Persistent measles infection in malnourished children.

Thirty malnourished and 25 well-nourished children were studied six to 31 days after the onset of a measles rash. Evidence of the virus was found in 40% of the malnourished children but in none of the well-nourished controls. Giant cells were found in the nasal secretions of five out of 17 malnourished children and measles antigen was detected in the lymphocytes of eight out of 28. The malnouri...

Measles-virus-persistent infection in BGM cells

In BGM cells chronically infected with measles virus, although the composition of the phospholipids is unaltered, the fatty acid composition is modified. Uninfected, lytic and persistently infected cells were labelled with [3Hlarachidonic acid and ['4C]stearic acid and their metabolic fate analysed. No difference in the total incorporation was observed in the different systems. However, the ["4...

Prevalence of urinary tract infection in severely malnourished preschool children.

Eighty eight severely malnourished preschool children (Grade III or Grade IV, IAP classification) were studied to find out the prevalence of urinary tract infection (UTI). Fifty three well nourished preschool children served as controls. Urine samples were collected by suprapubic aspiration in children below 3 years and in older children a clean catch midstream sample of urine was collected. Th...

Measles virus induces persistent infection by autoregulation of viral replication

Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by which this occurs is largely unknown. Here, we demonstrate that MV changes the inf...

Pathogenesis of Encephalitis Caused by Persistent Measles Virus Infection